Car T Cell Therapy

Introduction:

Intro 1:

CAR-T therapy is a method of enabling T cells, a type of white blood cell that targets foreign pathogens, to combat cancer by editing them in the lab to seek out and destroy cancer cells. T cells are extracted from the patient's blood and genetically modified in the lab by adding a gene for a man-made receptor (called CAR). This receptor helps the T cells better identify specific antigens on cancer cells. Once modified, the CAR-T cells are then infused back into the patient.

Intro 2:

CAR T-cell therapy, or Chimeric Antigen Receptor T-cell therapy, is a form of immunotherapy used to treat certain types of cancer. T cells are taken from patient's blood and are changed in lab by adding a gene for a man-made receptor (called CAR). This helps them better identify specific cancer cell antigens. CAR-T cells are then given back to the patient.

Benefits:

• CART technology holds promise of curing certain types of cancers.

• Unlike chemotherapy, CAR-T is administered only once to a patient.

• Short treatment time needed and more rapid recovery.

Challenges: 

• Severe life-threatening toxicities, 

• Modest anti-tumour activity, 

• Antigen escape, 

• Restricted trafficking, 

• Limited tumour infiltration etc.

Conclusion

In order to overcome challenges associated with CAR-T therapy, innovative strategies and approaches to engineer more powerful CAR-T cells with improved anti-tumour activity and decreased toxicity are necessary.